Emily (8) is terminally ill. Her parents ask the new CEO of a small pharmaceutical company, Dr. Julia Schemmel, for the early release of a drug that is not yet ready for the market. Dr. Julia Schemmel is to consolidate the company. The young company has to invest hundreds of millions of euros for each drug and is planning to go public. At the same time, Michael and Nicole Wagner receive the diagnosis that their daughter is suffering from incurable childhood dementia. During extensive internet research, Michael finds out that the pharmaceutical company "Berner & Braun" is researching a cure that has already been tested on people in Asia. It is said to slow down the progression of the disease, possibly even stop it. Together with other affected parents, the Wagners demand a study for children in Germany and the release of the drug.

In April 2009, Colonel Klein takes up his post as commander in Kunduz. The first soldiers move into the camp quarters. Among them are five young men who have so far been denied any field experience. So far, they have only known the mission in Afghanistan as an exercise. Colonel Klein is therefore faced with a difficult task, which turns the management of the camp into a crucial test. At that very moment, the Taliban's spring offensive breaks out against the Germans. The first casualties and deaths cannot be avoided and two tanker trucks are hijacked by the attackers. The war has begun. Months later, the stolen trucks are recovered. Both vehicles are stuck on a sandbank in the river. Klein has to decide whether the discovery poses a danger to his camp.

Rudger, ex-boyfriend of Jan's girlfriend Milene and biological father of their son, turns up at the practice of alternative practitioner Jan. He spent ten years in prison. Now he wants his wife and child back. It's clear to Jan that the man can't be helped with homeopathic doses. Heavy artillery must be brought to bear. Steve, a former colleague who has gone off the rails, promises to help. The operation goes wrong, Rudger rages and Jan flees to one of his patients. The terminally ill Dorothee has retreated to a mill - and has nothing to lose...

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Architect shuttles between two husbands.

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Hanna Forster is still waiting eagerly for the return of her husband Karl, who has been in Russian captivity for seven years. Hanna brought the family and joinery on her own through the war and post-war years. When Karl finally returns, Hanna is overjoyed, but luck does not last long. Heavily injured and traumatized, Karl finds it difficult to get used to everyday and family life again. To prevent the bankruptcy of the joinery, Hanna makes a momentous decision.

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Ella and Marcus Herlinger want a child. However, Ella is the carrier of the hereditary Duchenne disease.

Dedicated public prosecutor Judith Schrader is once again fighting organized crime in Berlin. This time she is investigating security companies that are increasingly in the hands of the OC.